I’ve done that for over a decade (12 years).
Healthy plant material makes a healthy new plant. Just don’t clone anything that looks outside of norm.
A sport mutation occurs on a single branch, generally it has a phenotype that differs from all of the other branches. I only clone fresh top growth. I won’t clone anything with leaves that looked bent, twisted, wrinkly, etc. Clone branches that look most ideal, skip everything else.
The reality is a sport mutation will happen on a mother too. It might even be more likely due some of those clone sites being quite old in comparison. I do mothers now out of necessity. I still only take the most perfect examples of the plant, tops only, nothing below a foot from the top of the canopy. I get about 50 in round 1, 25 in round 2, and maybe 10 or 12 in the last round and then I think the mother looks like trash and I pitch her in the compost pile. Then I double those clones for the season, turning 2000 in 4000, by way of clones from clones.
When selecting next year’s clones from the field, I take 15 clones, 1 from 15 different individuals of a strain. I select the best plant in the best spot, down to the best plant in the worse spot. I pot up all of the clones and grow them in 1 gallons until they need to go to 10 gallons. Of the 15 clones I keep 6 of the best 1 gallons to transplant. If anything, I may catch a sport that provides a benefit to the genetics, and looks better! But I won’t hold my breath…
I think spreading out source material lowers your probability of problems. The only way to wreck your line is to clone that 1 solitary sport that happens every 10 to 20 years, lose every other clone you took, and your line becomes that sport, good or bad, usually bad.